Query 'WD40 repeat domain' matched 43 Records
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Record No : 1 |
| Instance ID | 10159 | | Regular Expression | xRxxLxx[LIVM]x | | Motif Instance | HRKHLQEIP | | Bait Uniprot Accession | Q13309 | | Bait Uniprot Identifier | SKP2_HUMAN | | Bait Gene Name | SKP2 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 2-10 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Pull down; Radiolabel; Mutation analysis | | Interaction ID | 20159 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15014503 | | Comments | The APCC-binding Destruction motif (DBox) due to which the human F-box protein Skp2 is polyubiquitinated, and hence earmarked for destruction, by APC(CDH1) |
Record No : 2 |
| Instance ID | 10172 | | Regular Expression | xKENx | | Motif Instance | VKENL | | Bait Uniprot Accession | Q08981 | | Bait Uniprot Identifier | ACM1_YEAST | | Bait Gene Name | ACM1 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 97-101 | | Critical Residues | P2; P3; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20172 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18596038 | | Comments | KEN box motif in budding yeast Acm1 protein that is required for high affinity interaction with the substrate receptor site on the WD40 domain of Cdh1 that may serve both to promote APC inhibition and protect Acm1 from destruction |
Record No : 3 |
| Instance ID | 10173 | | Regular Expression | xKENx | | Motif Instance | AKENE | | Bait Uniprot Accession | O60566 | | Bait Uniprot Identifier | BUB1B_HUMAN | | Bait Gene Name | BUB1B | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 303-307 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis | | Interaction ID | 20173 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 22193957 | | Comments | Second KEN-box motif (303-307) of human Mitotic checkpoint kinase BUB1 beta, a subunit of the Spindle Assembly Checkpoint (SAC),that binds to the substrate recruitment site of human CDC20, the substrate recognition subunit of the Anaphase Promoting Complex/Cyclosome (APC/C), thereby blocking the recruitment of substrates to the APC/C |
Record No : 4 |
| Instance ID | 10174 | | Regular Expression | xKENx | | Motif Instance | SKENV | | Bait Uniprot Accession | O60566 | | Bait Uniprot Identifier | BUB1B_HUMAN | | Bait Gene Name | BUB1B | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 25-29 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | 3(10)-helix | | Experimental Method(s) | X-ray crystallography; Mutation analysis | | Interaction ID | 20174 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 23091007 | | Comments | Checkpoint inhibition of APC/C(Cdc20) requires the binding of the first BubR1 (BUB1B) KEN box (25-29) to Cdc20 |
Record No : 5 |
| Instance ID | 10241 | | Regular Expression | [DE][DE]xxxVP[DE] | | Motif Instance | EEPQTVPE | | Bait Uniprot Accession | P05412 | | Bait Uniprot Identifier | JUN_HUMAN | | Bait Gene Name | JUN | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 227-234 | | Critical Residues | P6; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP | | Interaction ID | 20241 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12615916 | | Comments | A consensus motif in human Transcription factor AP-1 (JUN) whose integrity is essential for the interaction with human E3 ubiquitin-protein ligase RFWD2 (or human COP1) causing suppression of AP-1-dependent transcription |
Record No : 6 |
| Instance ID | 10242 | | Regular Expression | [DE][DE]xxxVP[DE] | | Motif Instance | EEIRRVPE | | Bait Uniprot Accession | O24646 | | Bait Uniprot Identifier | HY5_ARATH | | Bait Gene Name | HY5 | | Bait Organism | Arabidopsis thaliana (Mouse-ear cress) | | Sequence Position | 38-45 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 20242 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9659918 | | Comments | Arabidopsis COP1 negatively regulates HY5, a bZIP protein and a positive regulator of photomorphogenic development, through a consensus COP1 binding motif |
Record No : 7 |
| Instance ID | 10243 | | Regular Expression | [DE][DE]xxxVP[DE] | | Motif Instance | EEHFLVPD | | Bait Uniprot Accession | Q9SID1 | | Bait Uniprot Identifier | STH_ARATH | | Bait Gene Name | STH | | Bait Organism | Arabidopsis thaliana (Mouse-ear cress) | | Sequence Position | 229-236 | | Critical Residues | P6; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Y2H | | Interaction ID | 20243 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11226162 | | Comments | A consensus COP1 binding motif in Arabidopsis Salt tolerance-like protein (STH) that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1 |
Record No : 8 |
| Instance ID | 10244 | | Regular Expression | [DE][DE]xxxVP[DE] | | Motif Instance | DEPQTVPD | | Bait Uniprot Accession | P17535 | | Bait Uniprot Identifier | JUND_HUMAN | | Bait Gene Name | JUND | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 241-248 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 20244 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12615916 | | Comments | A consensus motif in human Transcription factor jun-D whose integrity is essential for the interaction with human E3 ubiquitin-protein ligase RFWD2 (or human COP1) |
Record No : 9 |
| Instance ID | 10250 | | Regular Expression | [NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | MRVTDFFSQSKRG | | Bait Uniprot Accession | Q9I9A7 | | Bait Uniprot Identifier | CDT1_XENLA | | Bait Gene Name | cdt1 | | Bait Organism | Xenopus laevis (African clawed frog) | | Sequence Position | 4-16 | | Critical Residues | P11 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Co-IP; Ubiquitinase assay; Western blot; Alanine scanning; Mutation analysis | | Interaction ID | 20250 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 19595719 | | Comments | Docking of a specialized PIP Box motif of Xenopus DNA replication factor Cdt1 onto chromatin-bound PCNA creates a degron for the ubiquitin ligase CRL4Cdt3 |
Record No : 10 |
| Instance ID | 10253 | | Regular Expression | [NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | RRVTDFFARRRP | | Bait Uniprot Accession | Q9H211 | | Bait Uniprot Identifier | CDT1_HUMAN | | Bait Gene Name | CDT1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 4-15 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | RNA interference;Western blot; Co-IP | | Interaction ID | 20253 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16861906 | | Comments | The human homologue of Drosophila L2DTL or fission yeast CDT2 (DTL) interacts with PCNA and regulates human DNA replication factor CDT1 proteolysis in response to DNA damage, through the conserved PIP box motif |
Record No : 11 |
| Instance ID | 10255 | | Regular Expression | [NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | TSMTDFYHSKRRL | | Bait Uniprot Accession | P38936 | | Bait Uniprot Identifier | CDN1A_HUMAN | | Bait Gene Name | CDKN1A | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 145-157 | | Critical Residues | P10; P11; P12 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | Fluorescence technology; RNA interference; Ubiquitinase assay; Western blot; Co-IP; Alanine scanning; Co-IP | | Interaction ID | 20255 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18703516, 18794347 | | Comments | PCNA binding domain in CDK inhibitor p21 (CDKN1A) that is responsible for degradation of p21 by PCNA-coupled Cul4-DDB1(Cdt2)-dependent proteolysis |
Record No : 12 |
| Instance ID | 10257 | | Regular Expression | [NQ]{0,1}xx[ILMV][ST][DEN][FY][FY]x{2,3}[KR]{2,3}[^DE] | | Motif Instance | RKLTDFYPVRRS | | Bait Uniprot Accession | Q9NQR1 | | Bait Uniprot Identifier | SETD8_HUMAN | | Bait Gene Name | SETD8 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 220-231 | | Critical Residues | P6; P7 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | RNA interference;Western blot; Co-IP; Alanine scanning; Fluorescence technology; Mutation disrupting interaction; Ubiquitinase assay | | Interaction ID | 20257 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 20932472, 21220508 | | Comments | CDT2-mediated destruction of the histone methyltransferase SETD8 prevents premature chromatin compaction in S phase |
Record No : 13 |
| Instance ID | 10774 | | Regular Expression | F[EDQS][MILV][ED][MILV]((x{0,1}[ED])|($)) | | Motif Instance | FEMDI | | Bait Uniprot Accession | Q13541 | | Bait Uniprot Identifier | 4EBP1_HUMAN | | Bait Gene Name | EIF4EBP1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 114-118 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Western blot; Pull down; Mutation analysis | | Interaction ID | 20774 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12912989 | | Comments | The TOS motif in human translational repressor protein EIF4EBP1 (4E-BP1, also termed PHAS-I) acts as a docking site for the human TOR pathway adaptor protein RAPTOR |
Record No : 14 |
| Instance ID | 10775 | | Regular Expression | F[EDQS][MILV][ED][MILV]((x{0,1}[ED])|($)) | | Motif Instance | FDIDLD | | Bait Uniprot Accession | P23443 | | Bait Uniprot Identifier | KS6B1_HUMAN | | Bait Gene Name | RPS6KB1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 28-33 | | Critical Residues | P1; P2; P4 | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Mutation analysis | | Interaction ID | 20775 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11967149, 12912989 | | Comments | The TOS motif in human Ribosomal protein S6 kinase beta-1 (RPS6KB1) acts as a docking site for the human TOR pathway adaptor protein RAPTOR |
Record No : 15 |
| Instance ID | 10820 | | Regular Expression | [LIVMP]x{0,2}(T)Pxx([ST]) | | Motif Instance | PGTPPSS | | Bait Uniprot Accession | P13051 | | Bait Uniprot Identifier | UNG_HUMAN | | Bait Gene Name | UNG | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 58-64 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Thr-P3 | | Secondary Structure | Disordered | | Experimental Method(s) | Mass spectrometry; Mutation analysis | | Interaction ID | 20820 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18079698 | | Comments | The TPxxS phospho-dependent degron in Human Uracil-DNA glycosylase (UNG) that binds the F box protein FBW7 (also called FBXW7, hCdc4 or hSel10) of the SCF complex via WD40 beta propeller for subsequent ubiquitin-mediated degradation |
Record No : 16 |
| Instance ID | 10821 | | Regular Expression | [LIVMP]x{0,2}(T)Pxx([ST]) | | Motif Instance | LTPPPS | | Bait Uniprot Accession | P36956 | | Bait Uniprot Identifier | SRBP1_HUMAN | | Bait Gene Name | SREBF1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 425-430 | | Critical Residues | P2; P6 | | Motif PTM(s) | Phosphorylation at Thr-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Protein kinase assay; ChIP; Mutation analysis; Co-IP | | Interaction ID | 20821 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16825193, 16054087 | | Comments | The TPxxS phospho-dependent degron in Human Sterol regulatory element-binding protein 1 (SREBF1) that serves as a recognition motif for the SCF(FBW7) ubiquitin ligase and enhances its ubiquitination and degradation in a manner dependent on the phosphorylation of T426 and S430 |
Record No : 17 |
| Instance ID | 10822 | | Regular Expression | [LIVMP]x{0,2}(T)Pxx([ST]) | | Motif Instance | LLTPPQS | | Bait Uniprot Accession | P24864 | | Bait Uniprot Identifier | CCNE1_HUMAN | | Bait Gene Name | CCNE1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 393-399 | | Critical Residues | P3; P7 | | Motif PTM(s) | Phosphorylation at Thr-P3 & Ser-P7 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; ITC; Mutation analysis | | Interaction ID | 20822 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17434132, 14536078 | | Comments | The TPxxS phospho-dependent degron in Human G1/S-specific cyclin-E1 (CCNE1) that serves as a recognition motif for the SCF(FBW7) ubiquitin ligase, which mediates the degradation of cyclin E within catalytically active cyclin E-Cdk2 complexes and is not involved in the turnover of unbound or unphosphorylated cyclin E |
Record No : 18 |
| Instance ID | 10823 | | Regular Expression | [LIVMP]x{0,2}(T)Pxx([ST]) | | Motif Instance | LLPTPPLS | | Bait Uniprot Accession | P01106 | | Bait Uniprot Identifier | MYC_HUMAN | | Bait Gene Name | MYC | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 55-62 | | Critical Residues | P4; P8 | | Motif PTM(s) | Phosphorylation at Thr-P4 & Ser-P8 | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Competition binding; Co-IP; Ubiquitinase assay | | Interaction ID | 20823 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15992821, 15103331 | | Comments | Phosphorylation-dependent degradation of Human c-Myc is mediated by the F-box protein F box protein FBXW7 of the SCF complex in a manner dependent on the phosphorylation of threonine-58 and serine-62 |
Record No : 19 |
| Instance ID | 10824 | | Regular Expression | [LIVMP]x{0,2}(T)Pxx([ST]) | | Motif Instance | PGETPPLS | | Bait Uniprot Accession | P05412 | | Bait Uniprot Identifier | JUN_HUMAN | | Bait Gene Name | JUN | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 236-243 | | Critical Residues | P8 | | Motif PTM(s) | Phosphorylation at Ser-P8 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding to perpetrator; Mutation disrupting interaction; Competition binding | | Interaction ID | 20824 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 16023596 | | Comments | Phosphorylation of Human c-Jun by GSK3 at Ser-243 creates a high-affinity binding site for the E3 ligase FBW7, which targets c-Jun for polyubiquitination and proteasomal degradation |
Record No : 20 |
| Instance ID | 10825 | | Regular Expression | [LIVMP]x{0,2}(T)PxxE | | Motif Instance | PFLTPSPE | | Bait Uniprot Accession | P46531 | | Bait Uniprot Identifier | NOTC1_HUMAN | | Bait Gene Name | NOTCH1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 2508-2515 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 20825 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11585921, 11461910 | | Comments | The phospho-dependent degron in Human Neurogenic locus notch homolog protein 1 (NOTCH1) that binds the F-box/WD40 repeat protein FBW7 (also called FBXW7, hCdc4 or SEL-10), which leads to an increase in Notch signaling |
Record No : 21 |
| Instance ID | 10826 | | Regular Expression | [LIVMP]x{0,2}(T)PxxE | | Motif Instance | PPTPPPE | | Bait Uniprot Accession | P03070 | | Bait Uniprot Identifier | LT_SV40 | | Bait Gene Name | Not Available | | Bait Organism | Simian virus 40 (SV40) | | Sequence Position | 699-705 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Thr-P3 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Classical fluorescence spectroscopy; Mutation analysis | | Interaction ID | 20826 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 15611062 | | Comments | The SV40 large T antigen contains a decoy phosphodegron that mediates its interactions with the F box protein FBW7/FBXW7/hCdc4 |
Record No : 22 |
| Instance ID | 10830 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGLGS | | Bait Uniprot Accession | Q15653 | | Bait Uniprot Identifier | IKBB_HUMAN | | Bait Gene Name | NFKBIB | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 18-23 | | Critical Residues | P2; P6 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Radiolabel; Co-IP | | Interaction ID | 20830 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10497169 | | Comments | The DSGxxS phospho-dependent degron in human NF-kappa-B inhibitor beta (NFKBIB/IKBB) that binds the F-box/WD repeat-containing protein beta-TrCP (BTRC) of the SCF-betaTrCP1 complex leading to ubiquitination and degradation of IKBB |
Record No : 23 |
| Instance ID | 10831 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGIES | | Bait Uniprot Accession | O00221 | | Bait Uniprot Identifier | IKBE_HUMAN | | Bait Gene Name | NFKBIE | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 156-161 | | Critical Residues | P2; P6 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Radiolabel; Co-IP | | Interaction ID | 20831 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10497169 | | Comments | The DSGxxS phospho-dependent degron in human NF-kappa-B inhibitor epsilon (NFKBIE/IKBE) that binds the F-box/WD repeat-containing protein beta-TrCP (BTRC) of the SCF-betaTrCP1 complex leading to ubiquitination and degradation of IKBE |
Record No : 24 |
| Instance ID | 10832 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGIHS | | Bait Uniprot Accession | P35222 | | Bait Uniprot Identifier | CTNB1_HUMAN | | Bait Gene Name | CTNNB1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 32-37 | | Critical Residues | P1; P2; P3; P6 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | X-ray crystallography; Protein kinase assay | | Interaction ID | 20832 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12820959 | | Comments | The DSGxxS phospho-dependent degron present in human Beta-catenin (CTNNB1) that binds the F-box/WD repeat-containing protein beta-TrCP (BTRC), which recruits CTNNB1 to the SCF ubiquitin ligase complex |
Record No : 25 |
| Instance ID | 10833 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGVETS | | Bait Uniprot Accession | P19838 | | Bait Uniprot Identifier | NFKB1_HUMAN | | Bait Gene Name | NFKB1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 926-932 | | Critical Residues | P2; P7 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P7 | | Secondary Structure | Unknown | | Experimental Method(s) | Competition binding; Peptide binding to perpetrator; Protein kinase assay | | Interaction ID | 20833 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12482991 | | Comments | The DSGxxS phospho-dependent degron present in human Nuclear factor NF-kappa-B p105 subunit (NFKB1) that binds to the F-box/WD repeat-containing protein beta-TrCP (BTRC) for beta-TrCP-mediated proteolysis of NF-kappaB1 p105 |
Record No : 26 |
| Instance ID | 10834 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGLDS | | Bait Uniprot Accession | P25963 | | Bait Uniprot Identifier | IKBA_HUMAN | | Bait Gene Name | NFKBIA | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 31-36 | | Critical Residues | P2; P6 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Radiolabel; Mass spectrometry; Protein kinase assay; Peptide binding to perpetrator; Co-IP | | Interaction ID | 20834 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 10497169, 10230406, 9990852 | | Comments | The DSGxxS phospho-dependent degron in human NF-kappa-B inhibitor alpha (NFKBIA/IKBA) that binds to the F-box/WD repeat-containing protein beta-TrCP (BTRC), which recruits IKBA to the SCF ubiquitin ligase complex leading to its ubiquitination and degradation |
Record No : 27 |
| Instance ID | 10835 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGQGS | | Bait Uniprot Accession | Q9HAW4 | | Bait Uniprot Identifier | CLSPN_HUMAN | | Bait Gene Name | CLSPN | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 29-34 | | Critical Residues | P2; P6 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Co-IP; Fluorescence-activated cell sorting | | Interaction ID | 20835 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 16885022 | | Comments | The DSGxxS phospho-dependent degron in Human Claspin (CLSPN) that binds to the F-box/WD repeat-containing protein beta-TrCP (BTRC) for SCF-betaTrCP complex-mediated degradation of Claspin, which regulates recovery from the DNA replication checkpoint response |
Record No : 28 |
| Instance ID | 10836 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGICMS | | Bait Uniprot Accession | P18848 | | Bait Uniprot Identifier | ATF4_HUMAN | | Bait Gene Name | ATF4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 218-224 | | Critical Residues | P1; P2 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P7 | | Secondary Structure | Unknown | | Experimental Method(s) | Y2H; Mutation analysis; Radiolabel; Protein kinase assay | | Interaction ID | 20836 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11238952 | | Comments | Degradation of human cAMP-dependent transcription factor ATF4 relies on a phosphorylation-dependent interaction with the SCF(betaTrCP) ubiquitin ligase via the DSGxxS phospho-dependent degron |
Record No : 29 |
| Instance ID | 10837 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGLPS | | Bait Uniprot Accession | Q12959 | | Bait Uniprot Identifier | DLG1_HUMAN | | Bait Gene Name | DLG1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 597-602 | | Critical Residues | P2; P6 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down; Western blot; Co-IP; RNA interference | | Interaction ID | 20837 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 12902344 | | Comments | The DSGxxS phospho-dependent degron present in human Disks large homolog 1 (DLG1) that mediates phosphorylation-dependent interaction with the beta-TrCP ubiquitin ligase receptor |
Record No : 30 |
| Instance ID | 10838 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGYSS | | Bait Uniprot Accession | Q9UKT4 | | Bait Uniprot Identifier | FBX5_HUMAN | | Bait Gene Name | FBXO5 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 144-149 | | Critical Residues | P2; P6 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Protein kinase assay; Knock out; Classical fluorescence spectroscopy | | Interaction ID | 20838 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 12791266 | | Comments | The DSGxxS phospho-dependent degron in human F-box only protein 5 (FBXO5) that binds the F-box/WD repeat-containing protein beta-TrCP (BTRC), a component of the SCF ubiquitin ligase complex |
Record No : 31 |
| Instance ID | 10839 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGYNT | | Bait Uniprot Accession | Q6PGQ7 | | Bait Uniprot Identifier | BORA_HUMAN | | Bait Gene Name | BORA | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 496-501 | | Critical Residues | P2; P6 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Thr-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Mass spectrometry; Protein kinase assay; Co-IP | | Interaction ID | 20839 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 18378770 | | Comments | The DSGxxS phospho-dependent degron in Human aurora borealis (BORA) that binds the F-box/WD repeat-containing protein beta-TrCP (BTRC), a component of the SCF ubiquitin ligase complex leading to BORA degradation, which is required for normal mitotic progression |
Record No : 32 |
| Instance ID | 10840 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGRGS | | Bait Uniprot Accession | P16471 | | Bait Uniprot Identifier | PRLR_HUMAN | | Bait Gene Name | PRLR | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 348-353 | | Critical Residues | P2 | | Motif PTM(s) | Phosphorylation at Ser-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | Peptide binding to perpetrator; Protein kinase assay; Co-IP | | Interaction ID | 20840 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15082796 | | Comments | The pituitary hormone prolactin (PRL) promotes interaction between Human Prolactin receptor (PRLR) and the F-box/WD repeat-containing protein beta-TrCP (BTRC), substrate recognition subunit of the SCF ubiquitin ligase complex, depending on phosphorylation of serine 349 |
Record No : 33 |
| Instance ID | 10841 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGNES | | Bait Uniprot Accession | P05923 | | Bait Uniprot Identifier | VPU_HV1BR | | Bait Gene Name | vpu | | Bait Organism | Human immunodeficiency virus type 1 group M subtype B (isolate BRU/LAI) (HIV-1) | | Sequence Position | 51-56 | | Critical Residues | P2 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | NMR; Radiolabel; Confocal microscopy | | Interaction ID | 20841 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Human immunodeficiency virus (HIV) infection | | Inhibitor(s) | Unknown | | Reference(s) | 14674748, 14561767 | | Comments | Phosphorylation of the HIV-1 protein Vpu at Ser52 and Ser56 within the DSGXXS motif is required for its interaction with the SCF-betaTrCP ubiquitin ligase complex, which triggers HIV receptor CD4 degradation by the proteasome |
Record No : 34 |
| Instance ID | 10842 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGHES | | Bait Uniprot Accession | P03230 | | Bait Uniprot Identifier | LMP1_EBVB9 | | Bait Gene Name | LMP1 | | Bait Organism | Epstein-Barr virus (strain B95-8) (HHV-4) (Human herpesvirus 4) | | Sequence Position | 210-215 | | Critical Residues | P3 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Mutation analysis | | Interaction ID | 20842 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Epstein-Barr Virus (EBV) infection | | Inhibitor(s) | Unknown | | Reference(s) | 14523018 | | Comments | The Epstein-Barr virus latent membrane protein 1 (LMP1) is a pseudo-substrate of the SCF-betaTrCP ubiquitin ligase complex and the interaction between LMP1 and the F-box protein beta-TrCP (BTRC) restricts the extent of LMP1-induced NF-kappaB signaling |
Record No : 35 |
| Instance ID | 10843 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGRGDS | | Bait Uniprot Accession | Q53EL6 | | Bait Uniprot Identifier | PDCD4_HUMAN | | Bait Gene Name | PDCD4 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 70-76 | | Critical Residues | P2 | | Motif PTM(s) | Phosphorylation at Ser-P2 | | Secondary Structure | Unknown | | Experimental Method(s) | Mutation analysis; Protein kinase assay; Mass spectrometry | | Interaction ID | 20843 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 17053147 | | Comments | The physical interaction between the tumor suppressor Programmed cell death protein 4 (PDCD4) and the F-box/WD repeat-containing protein beta-TrCP (BTRC) requires the DSGXX(X)S degron and is stimulated by phosphorylation on Ser67 of PDCD4 |
Record No : 36 |
| Instance ID | 10844 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGIDS | | Bait Uniprot Accession | P98174 | | Bait Uniprot Identifier | FGD1_HUMAN | | Bait Gene Name | FGD1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 282-287 | | Critical Residues | P2 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Ser-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Radiolabel; Alanine scanning | | Interaction ID | 20844 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Faciogenital dysplasia | | Inhibitor(s) | Unknown | | Reference(s) | 15743413 | | Comments | The DSGxxS phospho-dependent degron in human FGD1, the Cdc42 guanine nucleotide exchange factor (GEF) responsible for faciogenital dysplasia, that binds the F-box/WD repeat-containing protein beta-TrCP (BTRC), substrate recognition subunit of the SCF ubiquitin ligase complex |
Record No : 37 |
| Instance ID | 10845 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGIDS | | Bait Uniprot Accession | Q5JSP0 | | Bait Uniprot Identifier | FGD3_HUMAN | | Bait Gene Name | FGD3 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 75-80 | | Critical Residues | P2; P6 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Thr-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP; Classical fluorescence spectroscopy; Western blot; Alanine scanning | | Interaction ID | 20845 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Faciogenital dysplasia | | Inhibitor(s) | Unknown | | Reference(s) | 18363964 | | Comments | The DSGxxS phospho-dependent degron in human FGD3, a putative Cdc42 guanine nucleotide exchange factor (GEF), that binds the F-box/WD repeat-containing protein beta-TrCP (BTRC), substrate recognition subunit of the SCF ubiquitin ligase complex |
Record No : 38 |
| Instance ID | 10846 | | Regular Expression | D(S)Gx{2,3}([ST]) | | Motif Instance | DSGNYS | | Bait Uniprot Accession | P17181 | | Bait Uniprot Identifier | INAR1_HUMAN | | Bait Gene Name | IFNAR1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 534-539 | | Critical Residues | P2; P6 | | Motif PTM(s) | Phosphorylation at Ser-P2 & Thr-P6 | | Secondary Structure | Unknown | | Experimental Method(s) | Radiolabel; Ubiquitinase assay; Protein kinase assay; Co-IP; Mutation analysis; Pull down | | Interaction ID | 20846 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 15337770, 14532120 | | Comments | Ubiquitination, endocytosis, and lysosomal degradation of the IFNAR1 (interferon alpha receptor 1) subunit of the type I interferon (IFN) receptor is mediated by the SCF ubiquitin ligase complex through a phosphorylation-dependent interaction with F-box and WD repeats protein beta-TrCP2 (FBXW11) |
Record No : 39 |
| Instance ID | 11175 | | Regular Expression | [EN][FYLW][NSQ]xEE[ILMVF][^P][LIVMFA] | | Motif Instance | EFSLEEVLA | | Bait Uniprot Accession | P47074 | | Bait Uniprot Identifier | MAD3_YEAST | | Bait Gene Name | MAD3 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 378-386 | | Critical Residues | P1; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | X-ray crystallography; Pull down; Co-IP; Y2H; Mutation analysis | | Interaction ID | 21175 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17227844 | | Comments | The Gle2-binding-sequence (GLEBS) motif found in yeast Spindle assembly checkpoint component MAD3 protein binds to the WD40 domain of yeast Cell cycle arrest protein BUB3 |
Record No : 40 |
| Instance ID | 11176 | | Regular Expression | [EN][FYLW][NSQ]xEE[ILMVF][^P][LIVMFA] | | Motif Instance | EFNTEEILA | | Bait Uniprot Accession | P41695 | | Bait Uniprot Identifier | BUB1_YEAST | | Bait Gene Name | BUB1 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 333-341 | | Critical Residues | P1; P5 | | Motif PTM(s) | Unknown | | Secondary Structure | Alpha helix | | Experimental Method(s) | ITC; X-ray crystallography | | Interaction ID | 21176 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 17227844 | | Comments | The Gle2-binding-sequence (GLEBS) motif found in yeast Checkpoint serine/threonine-protein kinase BUB1 binds to the WD40 domain of yeast Cell cycle arrest protein BUB3 |
Record No : 41 |
| Instance ID | 11177 | | Regular Expression | [EN][FYLW][NSQ]xEE[ILMVF][^P][LIVMFA] | | Motif Instance | EFSFEELRA | | Bait Uniprot Accession | O43683 | | Bait Uniprot Identifier | BUB1_HUMAN | | Bait Gene Name | BUB1 | | Bait Organism | Homo sapiens (Human) | | Sequence Position | 248-256 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Pull down | | Interaction ID | 21177 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Cancer | | Inhibitor(s) | Unknown | | Reference(s) | 11352911 | | Comments | The Gle2-binding-sequence (GLEBS) motif found in human Mitotic checkpoint serine/threonine-protein kinase BUB1 binds to the WD40 domain of human Mitotic checkpoint protein BUB3 |
Record No : 42 |
| Instance ID | 11178 | | Regular Expression | [EN][FYLW][NSQ]xEE[ILMVF][^P][LIVMFA] | | Motif Instance | NFSFEELRF | | Bait Uniprot Accession | Q02630 | | Bait Uniprot Identifier | NU116_YEAST | | Bait Gene Name | NUP116 | | Bait Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) | | Sequence Position | 150-158 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Co-IP | | Interaction ID | 21178 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 9463388 | | Comments | The Gle2-binding-sequence (GLEBS) motif found within yeast Nucleoporin Nup116p is sufficient and necessary to anchor yeast Nucleoporin Gle2p at the nuclear pores |
Record No : 43 |
| Instance ID | 11987 | | Regular Expression | TPxx[SE] | | Motif Instance | TPSPE | | Bait Uniprot Accession | Q01705 | | Bait Uniprot Identifier | NOTC1_MOUSE | | Bait Gene Name | Notch1 | | Bait Organism | Mus musculus (Mouse) | | Sequence Position | 2487-2491 | | Critical Residues | Unknown | | Motif PTM(s) | Unknown | | Secondary Structure | Unknown | | Experimental Method(s) | Sequence based prediction | | Interaction ID | 21987 | | Interacting Domain | WD40 repeat domain | | Disease Association(s) | Unknown | | Inhibitor(s) | Unknown | | Reference(s) | 11461910 | | Comments | The mouse Neurogenic locus notch homolog protein 1 (Notch1) intracellular domain is ubiquitinated and negatively regulated by the mouse F-box/WD repeat-containing protein 7 (Fbxw7) through a phosphodegron motif recognized by WD40 beta propeller |
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